VAX2

Across TCGA cell cohorts, VAX2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VAX2-associated genes across cancer lineages are DEFA4, CCDC182, and PRR23B. Each is linked with VAX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAX2-to-partner and partner-to-VAX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by VAX2-low versus VAX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAX2→partner) and Y-score (partner→VAX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CCDC182 →	+0.036	+3.217	<.001	.006	3	1
LARGE_INTESTINE	PRR23B →	+0.003	+3.217	<.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.056	+3.426	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DEFA4 by VAX2 expression — LARGE_INTESTINE

Explore this box plot interactively →