VAV3

Across TCGA pan-cancer cohorts, VAV3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VAV3 data layer compared with 18 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VAV3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VAV3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where VAV3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.913	0.705	.005	17	view →
LUAD	OS	Median	III,IV	0.315	0.750	.009	14	view →
PDAC	DFS	Median	II,III,IV	0.617	0.899	.007	7	view →
LSCC	OS	Median	III,IV	1.000	0.739	.008	6	view →
GBM	OS	Tertile	All	0.657	0.323	.014	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VAV3–CCRCC (DFS)

Open the CCRCC breakdown →