VAV3

Across TCGA patient cohorts, VAV3 mutation is significantly associated with the RNA expression of many other genes, with 3,327 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAV3-associated genes across cancer lineages are NCAPD3, ATP5F1A, and SFXN1. Each is linked with VAV3 in more than 2 cancer types. Because this analysis shows association rather than direction, both VAV3-to-partner and partner-to-VAV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPD3 grouped by VAV3-low versus VAV3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV3→partner) and Y-score (partner→VAV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPD3 →	+0.621	+2.329	<.001	<.001	3	3
UCEC	ATP5F1A →	+0.392	+2.490	.002	.001	3	3
UCEC	SFXN1 →	+0.434	+2.523	<.001	<.001	3	3
UCEC	RAB8A →	+0.333	+2.399	.001	<.001	3	3
UCEC	MRM3 →	+0.510	+2.797	<.001	<.001	3	3
UCEC	SNRNP40 →	+0.435	+1.555	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,327 associations by consensus.

NCAPD3 by VAV3 expression — UCEC

Explore this box plot interactively →