VAV3

Across TCGA cell cohorts, VAV3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,065 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VAV3-associated GO terms across cancer lineages are Negative regulation of peptidase activity, Positive regulation of collagen biosynthetic process, and T cell mediated immunity. Each is linked with VAV3 in more than 8 cancer types. Because this analysis shows association rather than direction, both VAV3-to-partner and partner-to-VAV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of peptidase activity grouped by VAV3-low versus VAV3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV3→partner) and Y-score (partner→VAV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of peptidase activity →	-0.756	-1.701	.001	.002	3	9
KIDNEY	Positive regulation of collagen biosynthetic process →	-0.177	-2.729	<.001	.001	3	8
OVARY	T cell mediated immunity →	+0.177	+2.443	<.001	.002	3	8
OVARY	Regulation of neurotrophin production →	+0.803	+1.879	.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of collagen metabolic process →	-0.157	-1.865	<.001	.002	2	8
UPPER_AERODIGESTIVE_TRACT	Regulation of collagen biosynthetic process →	-0.137	-1.723	.002	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,065 associations by consensus.

Negative regulation of peptidase activity by VAV3 expression — BREAST

Explore this box plot interactively →