VAV3

Across TCGA cell cohorts, VAV3 mutation is significantly associated with the RNA expression of many other genes, with 230 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VAV3-associated genes across cancer lineages are OR51T1, GSG1L2, and HTR5A. Each is linked with VAV3 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAV3-to-partner and partner-to-VAV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51T1 grouped by VAV3-low versus VAV3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV3→partner) and Y-score (partner→VAV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	2
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	2
SOFT_TISSUE	HTR5A →	+0.196	+4.930	<.001	.008	3	1
OVARY	KRT82 →	+0.009	+3.700	<.001	.005	3	1
OVARY	C22orf42 →	+0.034	+3.938	<.001	.005	3	1
OVARY	RBMY1J →	+0.014	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 230 associations by consensus.

OR51T1 by VAV3 expression — BLOOD_Leukemia

Explore this box plot interactively →