VAV1

Across TCGA pan-cancer cohorts, VAV1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated VAV1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher VAV1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VAV1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

MESO, ACC, and BLCA are the cancer types where VAV1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.098	0.579	.001	36	view →
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
BLCA	DFS	Median	All	1.000	0.318	.007	26	view →
LIHC	OS	Median	II,III,IV	0.051	0.716	<.001	24	view →
HNSC	DFS	Median	All	0.128	0.627	.003	18	view →
UCEC	DFS	Median	All	0.942	0.619	.007	18	view →
SCLC	OS	Median	III,IV	0.082	0.639	<.001	12	view →
LGG	DFS	Median	All	0.417	0.739	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

VAV1–MESO (OS)

Open the MESO breakdown →