VAV1

Across TCGA pan-cancer cohorts, VAV1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VAV1 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher VAV1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VAV1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

COAD, LUAD, and PDAC are the cancer types where VAV1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.834	1.000	.016	54	view →
LUAD	DFS	Tertile	All	0.762	0.472	.020	5	view →
PDAC	DFS	Median	II,III,IV	0.322	0.499	.036	5	view →
GBM	OS	Tertile	All	0.257	0.480	.028	4	view →
HNSC	DFS	Tertile	All	0.915	0.991	.037	3	view →
LSCC	DFS	Median	II,III,IV	0.550	0.822	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VAV1–COAD (DFS)

Open the COAD breakdown →