VAV1

Across TCGA patient cohorts, VAV1 mutation is significantly associated with the RNA expression of many other genes, with 2,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAV1-associated genes across cancer lineages are MYO19, NR2C2AP, and CYCSP41. Each is linked with VAV1 in more than 2 cancer types. Because this analysis shows association rather than direction, both VAV1-to-partner and partner-to-VAV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO19 grouped by VAV1-low versus VAV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV1→partner) and Y-score (partner→VAV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO19 →	+0.458	+2.202	<.001	<.001	3	3
UCEC	NR2C2AP →	+0.303	+1.890	.006	.004	3	3
CESC	CYCSP41 →	+0.167	+5.144	<.001	.003	3	3
SKCM	SLC35G1 →	+0.367	+2.597	.005	<.001	3	3
LUAD	TAPBPL →	-0.741	-3.412	.001	.005	3	3
COAD	WNT11 →	-1.254	-2.308	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,668 associations by consensus.

MYO19 by VAV1 expression — UCEC

Explore this box plot interactively →