VAV1

Across TCGA patient cohorts, VAV1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAV1-associated genes across cancer lineages are eEF2, JNK_pT183_Y185, and Cyclin-B1. Each is linked with VAV1 in more than 4 cancer types. Because this analysis shows association rather than direction, both VAV1-to-partner and partner-to-VAV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by VAV1-low versus VAV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV1→partner) and Y-score (partner→VAV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.247	+1.678	.030	.021	3	5
UCEC	JNK_pT183_Y185 →	-0.179	-2.502	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.646	+2.502	<.001	.001	3	3
SKCM	A-Raf_pS299 →	-0.165	-3.169	.002	.017	3	2
UCEC	Rab25 →	-0.378	-2.700	<.001	.005	3	2
SKCM	RBM15 →	+0.330	+1.415	.022	.045	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

eEF2 by VAV1 expression — UCEC

Explore this box plot interactively →