VAV1

Across TCGA cell cohorts, VAV1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,444 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VAV1-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of actin filament bundle assembly, and Lactone catabolic process. Each is linked with VAV1 in more than 6 cancer types. Because this analysis shows association rather than direction, both VAV1-to-partner and partner-to-VAV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by VAV1-low versus VAV1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV1→partner) and Y-score (partner→VAV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of myoblast fusion →	+0.104	+1.801	<.001	.003	3	7
LUNG_NSCLC_LUSC	Negative regulation of actin filament bundle assembly →	+0.088	+1.643	.009	.009	3	7
BLOOD_Leukemia	Lactone catabolic process →	-0.977	-0.914	<.001	<.001	3	7
BONE	Regulation of DNA repair →	+0.084	+2.805	<.001	<.001	3	6
URINARY_TRACT	Actomyosin contractile ring organization →	+0.157	+0.683	.008	.009	2	7
LARGE_INTESTINE	Positive regulation of protein localization to nucleus →	+0.068	+0.840	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,444 associations by consensus.

Regulation of myoblast fusion by VAV1 expression — OVARY

Explore this box plot interactively →