VAV1

Across TCGA cell cohorts, VAV1 mutation is significantly associated with the RNA expression of many other genes, with 272 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VAV1-associated genes across cancer lineages are BPIFB6, OPRPN, and TARM1. Each is linked with VAV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAV1-to-partner and partner-to-VAV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by VAV1-low versus VAV1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAV1→partner) and Y-score (partner→VAV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BPIFB6 →	+0.012	+5.029	.001	.006	3	2
URINARY_TRACT	OPRPN →	+0.045	+4.087	<.001	.009	3	1
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.014	+4.662	<.001	.005	3	1
BLOOD_Leukemia	MORN5 →	+0.143	+3.855	.005	.007	3	1
LARGE_INTESTINE	CBY1 →	+0.751	+3.330	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 272 associations by consensus.

BPIFB6 by VAV1 expression — LUNG_SCLC

Explore this box plot interactively →