VAT1L

Across TCGA patient cohorts, VAT1L mutation is significantly associated with the RNA expression of many other genes, with 4,749 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAT1L-associated genes across cancer lineages are PSMA3, CA15P2, and UHRF1. Each is linked with VAT1L in more than 3 cancer types. Because this analysis shows association rather than direction, both VAT1L-to-partner and partner-to-VAT1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMA3 grouped by VAT1L-low versus VAT1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAT1L→partner) and Y-score (partner→VAT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMA3 →	+0.386	+2.399	<.001	<.001	3	4
BRCA	CA15P2 →	+0.073	+5.122	<.001	.008	3	3
UCEC	UHRF1 →	+0.782	+2.389	<.001	<.001	3	3
SKCM	PSMC1 →	+0.391	+1.669	<.001	<.001	3	3
SKCM	MICU1 →	+0.408	+1.669	<.001	<.001	3	3
UCEC	NCAPG →	+0.702	+3.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,749 associations by consensus.

PSMA3 by VAT1L expression — UCEC

Explore this box plot interactively →