VAT1

Across TCGA pan-cancer cohorts, VAT1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VAT1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher VAT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VAT1 expression acts as an unfavorable survival marker.

COAD, HNSC, and UCEC are the cancer types where VAT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.898	1.000	.047	6	view →
HNSC	DFS	Median	All	0.355	0.854	.030	6	view →
UCEC	OS	Quartile	III,IV	0.280	0.807	.027	4	view →
LUAD	OS	Quartile	III,IV	0.316	0.685	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VAT1–COAD (DFS)

Open the COAD breakdown →