VAT1

Across TCGA patient cohorts, VAT1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAT1-associated genes across cancer lineages are eEF2, AMPK_alpha, and STAT3_pY705. Each is linked with VAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAT1-to-partner and partner-to-VAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by VAT1-low versus VAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAT1→partner) and Y-score (partner→VAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.574	+2.999	.002	.035	3	1
UCEC	AMPK_alpha →	-0.264	-3.000	.008	.036	3	1
UCEC	STAT3_pY705 →	-0.455	-3.159	<.001	.019	3	1
UCEC	TIGAR →	+0.193	+3.348	.015	.005	3	1
UCEC	ETS-1 →	+0.391	+3.000	.018	.036	2	1
UCEC	MSH2 →	-0.432	-2.990	<.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eEF2 by VAT1 expression — UCEC

Explore this box plot interactively →