VAT1

Across TCGA cell cohorts, VAT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,065 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VAT1-associated GO terms across cancer lineages are Autophagosome-lysosome fusion, Positive regulation of vacuole organization, and Intermembrane phospholipid transfer. Each is linked with VAT1 in more than 12 cancer types. Because this analysis shows association rather than direction, both VAT1-to-partner and partner-to-VAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Autophagosome-lysosome fusion grouped by VAT1-low versus VAT1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VAT1→partner) and Y-score (partner→VAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Autophagosome-lysosome fusion →	+0.110	+1.360	<.001	.009	3	13
LUNG_NSCLC_LUAD	Positive regulation of vacuole organization →	+0.080	+0.957	<.001	.002	3	12
BLOOD_Leukemia	Intermembrane phospholipid transfer →	+0.154	+1.946	<.001	<.001	3	11
SOFT_TISSUE	Actin filament depolymerization →	+0.147	+1.403	<.001	<.001	3	11
LARGE_INTESTINE	Positive regulation of receptor localization to synapse →	+0.187	+1.117	<.001	<.001	3	11
OESOPHAGUS	Regulation of endocytosis →	+0.054	+1.241	<.001	.006	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,065 associations by consensus.

Autophagosome-lysosome fusion by VAT1 expression — BONE

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