VASN

Across TCGA pan-cancer cohorts, VASN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VASN data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher VASN mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated VASN expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

UCEC, GBM, and HNSC are the cancer types where VASN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.494	1.000	.016	16	view →
GBM	DFS	Median	All	0.298	0.446	.009	15	view →
HNSC	DFS	Median	III,IV	0.853	0.702	.019	13	view →
PDAC	OS	Tertile	All	0.304	0.490	.028	13	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VASN–UCEC (OS)

Open the UCEC breakdown →