VASN

Across TCGA patient cohorts, VASN mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VASN-associated genes across cancer lineages are FOXO3a_pS318_S321, Notch1, and p27_pT198. Each is linked with VASN in more than 1 cancer types. Because this analysis shows association rather than direction, both VASN-to-partner and partner-to-VASN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by VASN-low versus VASN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VASN→partner) and Y-score (partner→VASN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.198	-3.000	.006	.037	3	1
UCEC	Notch1 →	+0.239	+2.820	.003	.035	3	1
UCEC	p27_pT198 →	+0.148	+3.000	.017	.037	3	1
UCEC	TIGAR →	+0.405	+3.026	<.001	.019	3	1
UCEC	EGFR_pY1068 →	-0.296	-3.000	.041	.037	2	1
UCEC	PCNA →	+0.351	+3.000	.004	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FOXO3a_pS318_S321 by VASN expression — UCEC

Explore this box plot interactively →