VASH2

Across TCGA patient cohorts, VASH2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VASH2-associated genes across cancer lineages are ACC1, 14-3-3_beta, and p62 Lck ligand. Each is linked with VASH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VASH2-to-partner and partner-to-VASH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by VASH2-low versus VASH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VASH2→partner) and Y-score (partner→VASH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.299	+2.335	.036	.018	3	2
UCEC	14-3-3_beta →	-0.084	-3.143	.033	.018	3	1
UCEC	p62 Lck ligand →	+0.284	+1.584	.026	.036	3	1
UCEC	PDK1_pS241 →	+0.180	+2.459	.007	.019	3	1
UCEC	Annexin_VII →	-0.116	-2.000	.033	.010	3	1
UCEC	Tuberin →	+0.235	+1.884	.026	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ACC1 by VASH2 expression — UCEC

Explore this box plot interactively →