VASH2

Across TCGA cell cohorts, VASH2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VASH2-associated genes across cancer lineages are CER1, DPPA3, and OR10H5. Each is linked with VASH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VASH2-to-partner and partner-to-VASH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CER1 grouped by VASH2-low versus VASH2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VASH2→partner) and Y-score (partner→VASH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CER1 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	DPPA3 →	+0.020	+6.247	<.001	<.001	3	1
SKIN	OR10H5 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	TMEM132B →	+0.473	+3.374	.003	.005	3	1
LARGE_INTESTINE	ZAN →	+0.014	+3.619	<.001	<.001	3	1
LARGE_INTESTINE	SAXO1 →	+0.041	+3.374	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CER1 by VASH2 expression — BLOOD_Lymphoma

Explore this box plot interactively →