VARS2

Across TCGA patient cohorts, VARS2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,618 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VARS2-associated genes across cancer lineages are FAS, ATP8B4, and DCN. Each is linked with VARS2 in more than 6 cancer types. Because this analysis shows association rather than direction, both VARS2-to-partner and partner-to-VARS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VARS2 versus FAS in BRCA, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VARS2→partner) and Y-score (partner→VARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAS →	-0.669	-0.339	<.001	<.001	3	7
UCEC	ATP8B4 →	-0.580	-0.303	<.001	<.001	3	6
GBM	DCN →	-1.309	-0.230	<.001	<.001	3	6
BRCA	GIMAP6 →	-0.906	-0.392	<.001	<.001	3	6
BRCA	GLIPR1 →	-0.774	-0.410	<.001	<.001	3	6
OV	LUM →	-1.375	-0.299	.008	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,618 associations by consensus.

VARS2 vs FAS — BRCA

Explore this scatter interactively →