VARS2

Across TCGA patient cohorts, VARS2 mutation is significantly associated with the RNA expression of many other genes, with 3,264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VARS2-associated genes across cancer lineages are RNU1-62P, SNRPGP12, and RN7SL822P. Each is linked with VARS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both VARS2-to-partner and partner-to-VARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-62P grouped by VARS2-low versus VARS2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VARS2→partner) and Y-score (partner→VARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-62P →	+0.238	+5.539	<.001	.004	3	3
KIRP	SNRPGP12 →	+0.227	+5.928	.003	.002	3	3
KIRP	RN7SL822P →	+0.171	+5.628	<.001	.004	3	3
BLCA	OR4C4P →	+0.016	+4.040	<.001	.007	3	3
UCEC	YARS1 →	+0.545	+4.031	<.001	<.001	3	3
STAD	C18orf21 →	+0.486	+3.203	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,264 associations by consensus.

RNU1-62P by VARS2 expression — CESC

Explore this box plot interactively →