VARS2

Across TCGA cell cohorts, VARS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,360 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible VARS2-associated GO terms across cancer lineages are Aminoacyl-tRNA metabolism involved in translational fidelity, Regulation of translational fidelity, and Negative regulation of RNA export from nucleus. Each is linked with VARS2 in more than 16 cancer types. Because this analysis shows association rather than direction, both VARS2-to-partner and partner-to-VARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aminoacyl-tRNA metabolism involved in translational fidelity grouped by VARS2-low versus VARS2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VARS2→partner) and Y-score (partner→VARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Aminoacyl-tRNA metabolism involved in translational fidelity →	+0.150	+1.604	<.001	<.001	3	17
SKIN	Regulation of translational fidelity →	+0.093	+0.783	<.001	<.001	3	13
LARGE_INTESTINE	Negative regulation of RNA export from nucleus →	+0.080	+0.891	.002	<.001	3	12
URINARY_TRACT	Base-excision repair, gap-filling →	+0.117	+1.192	.001	<.001	3	12
SOFT_TISSUE	Positive regulation of monoatomic ion transport →	-0.080	-0.650	<.001	<.001	3	12
SOFT_TISSUE	Positive regulation of monoatomic ion transmembrane transport →	-0.098	-0.798	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,360 associations by consensus.

Aminoacyl-tRNA metabolism involved in translational fidelity by VARS2 expression — URINARY_TRACT

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