VARS2

Across TCGA cell cohorts, VARS2 mutation is significantly associated with the RNA expression of many other genes, with 334 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VARS2-associated genes across cancer lineages are HSFY2, SLCO1C1, and CX3CR1. Each is linked with VARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VARS2-to-partner and partner-to-VARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY2 grouped by VARS2-low versus VARS2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VARS2→partner) and Y-score (partner→VARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HSFY2 →	+0.030	+3.209	<.001	.007	3	2
LARGE_INTESTINE	SLCO1C1 →	+0.345	+2.450	<.001	.007	3	2
LARGE_INTESTINE	CX3CR1 →	+0.192	+3.667	<.001	<.001	3	2
URINARY_TRACT	USP29 →	+0.033	+5.087	<.001	.004	3	1
URINARY_TRACT	SPHKAP →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	SPZ1 →	+0.056	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

HSFY2 by VARS2 expression — STOMACH

Explore this box plot interactively →