Across TCGA pan-cancer cohorts, VARS1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated VARS1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher VARS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VARS1 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where VARS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	1.000	0.895	.039	18	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	9	view →
CCRCC	DFS	Quartile	All	0.574	1.000	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: VARS1 tumor-vs-normal RNA expression · all VARS1 data types