Across TCGA cell cohorts, VARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,128 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VARS1-associated GO terms across cancer lineages are 'de novo' IMP biosynthetic process, Transcription initiation at RNA polymerase I promoter, and Maturation of SSU-rRNA. Each is linked with VARS1 in more than 16 cancer types. Because this analysis shows association rather than direction, both VARS1-to-partner and partner-to-VARS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VARS1→partner) and Y-score (partner→VARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	'de novo' IMP biosynthetic process →	+0.218	+1.157	<.001	<.001	3	17
BONE	Transcription initiation at RNA polymerase I promoter →	+0.138	+1.125	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Maturation of SSU-rRNA →	+0.130	+1.167	.001	<.001	3	17
PANCREAS	IMP biosynthetic process →	+0.187	+1.520	<.001	<.001	3	16
BONE	Negative regulation of RNA export from nucleus →	+0.168	+1.186	<.001	<.001	3	16
BONE	rRNA processing →	+0.153	+0.956	<.001	.007	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,128 associations by consensus.

Exploration

VARS1 survival (RNA) · tumor vs normal (RNA) · all VARS1 data types