VAPB

Across TCGA patient cohorts, VAPB protein abundance is significantly associated with the RNA expression of many other genes, with 18,222 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VAPB-associated genes across cancer lineages are RAB22A, OSBPL2, and LSM14B. Each is linked with VAPB in more than 6 cancer types. Because this analysis shows association rather than direction, both VAPB-to-partner and partner-to-VAPB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VAPB versus RAB22A in HNSC, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAPB→partner) and Y-score (partner→VAPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RAB22A →	+0.573	+0.315	<.001	<.001	3	7
COAD	OSBPL2 →	+0.547	+0.255	<.001	<.001	3	6
COAD	LSM14B →	+0.594	+0.326	<.001	<.001	3	6
LUAD	SS18L1 →	+0.588	+0.441	<.001	<.001	3	6
OV	RTF2 →	+0.484	+0.343	.001	.003	3	6
COAD	LILRB2 →	-0.841	-0.312	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,222 associations by consensus.

VAPB vs RAB22A — HNSC

Explore this scatter interactively →