VAPB

Across TCGA patient cohorts, VAPB mutation is significantly associated with the RNA expression of many other genes, with 2,829 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAPB-associated genes across cancer lineages are POM121C, DOC2B, and MAP3K4-AS1. Each is linked with VAPB in more than 1 cancer types. Because this analysis shows association rather than direction, both VAPB-to-partner and partner-to-VAPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POM121C grouped by VAPB-low versus VAPB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAPB→partner) and Y-score (partner→VAPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POM121C →	+0.434	+3.483	.001	.002	3	1
UCEC	DOC2B →	-1.255	-3.087	<.001	<.001	3	1
UCEC	MAP3K4-AS1 →	+0.777	+3.815	<.001	<.001	3	1
UCEC	CWC25 →	+0.416	+3.922	.003	<.001	3	1
UCEC	CYFIP1 →	+0.494	+2.447	.005	.001	3	1
UCEC	TMEM269 →	+0.201	+3.324	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,829 associations by consensus.

POM121C by VAPB expression — UCEC

Explore this box plot interactively →