VAPB

Across TCGA patient cohorts, VAPB mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAPB-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with VAPB in more than 1 cancer types. Because this analysis shows association rather than direction, both VAPB-to-partner and partner-to-VAPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by VAPB-low versus VAPB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAPB→partner) and Y-score (partner→VAPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.276	-2.321	.007	.034	3	1
UCEC	eIF4E →	+0.183	+2.459	.036	.019	3	1
UCEC	A-Raf_pS299 →	-0.159	-2.321	.001	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.109	-2.000	.034	.029	3	1
UCEC	G6PD →	-0.277	-3.156	.038	.018	3	1
UCEC	Gab2 →	+0.412	+2.321	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by VAPB expression — UCEC

Explore this box plot interactively →