VAPA

Across TCGA pan-cancer cohorts, VAPA mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of VAPA’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VAPA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types VAPA is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and HNSC are the cancer types where VAPA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VAPA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.208	<.001	11	view →
CCRCC	Female	All	−0.242	<.001	8	view →
HNSC	All	III,IV	+0.178	.001	6	view →
LUAD	Male	All	+0.155	<.001	4	view →
PDAC	All	IV	+0.560	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

VAPA–COAD

Open the COAD breakdown →