VAPA

Across TCGA patient cohorts, VAPA mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAPA-associated genes across cancer lineages are ATM, 4E-BP1, and eEF2. Each is linked with VAPA in more than 1 cancer types. Because this analysis shows association rather than direction, both VAPA-to-partner and partner-to-VAPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by VAPA-low versus VAPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAPA→partner) and Y-score (partner→VAPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.733	-3.446	<.001	.005	3	2
UCEC	4E-BP1 →	+0.397	+3.169	<.001	.018	3	2
UCEC	eEF2 →	+0.492	+3.321	.001	.010	3	1
UCEC	EGFR_pY1068 →	-0.279	-2.807	.010	.003	3	1
UCEC	ERK2 →	+0.249	+3.321	.003	.009	3	1
UCEC	GAPDH →	+0.581	+3.321	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by VAPA expression — UCEC

Explore this box plot interactively →