VAPA

Across TCGA cell cohorts, VAPA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,324 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VAPA-associated GO terms across cancer lineages are Negative regulation of macrophage colony-stimulating factor signaling pathway, Regulation of mitochondrial transcription, and Myoblast migration. Each is linked with VAPA in more than 13 cancer types. Because this analysis shows association rather than direction, both VAPA-to-partner and partner-to-VAPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macrophage colony-stimulating factor signaling pathway grouped by VAPA-low versus VAPA-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VAPA→partner) and Y-score (partner→VAPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of macrophage colony-stimulating factor signaling pathway →	+0.263	+1.019	<.001	<.001	3	14
BREAST	Regulation of mitochondrial transcription →	+0.105	+0.710	<.001	<.001	3	9
BREAST	Myoblast migration →	+0.160	+0.898	<.001	<.001	3	9
BONE	Cellular response to abiotic stimulus →	+0.041	+1.014	.004	.003	3	8
LARGE_INTESTINE	Regulation of mitochondrial fission →	+0.112	+0.834	<.001	<.001	3	8
STOMACH	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.070	+0.782	.006	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,324 associations by consensus.

Negative regulation of macrophage colony-stimulating factor signaling pathway by VAPA expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →