VAPA

Across TCGA cell cohorts, VAPA mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VAPA-associated genes across cancer lineages are MSGN1, MCHR2, and SPRR2F. Each is linked with VAPA in more than 1 cancer types. Because this analysis shows association rather than direction, both VAPA-to-partner and partner-to-VAPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by VAPA-low versus VAPA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAPA→partner) and Y-score (partner→VAPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	MCHR2 →	+0.017	+5.099	.004	<.001	3	1
LARGE_INTESTINE	SPRR2F →	+0.629	+3.707	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MSGN1 by VAPA expression — LARGE_INTESTINE

Explore this box plot interactively →