VANGL2

Across TCGA patient cohorts, VANGL2 protein abundance is significantly associated with the RNA expression of many other genes, with 15,575 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VANGL2-associated genes across cancer lineages are ARL8A, IPO9, and SLAMF1. Each is linked with VANGL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both VANGL2-to-partner and partner-to-VANGL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VANGL2 versus ARL8A in BRCA, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VANGL2→partner) and Y-score (partner→VANGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARL8A →	+0.492	+0.612	.002	.001	3	5
LSCC	IPO9 →	+0.529	+0.418	<.001	<.001	3	5
HNSC	SLAMF1 →	-0.686	-0.336	<.001	.004	3	5
LSCC	OLFM2 →	+0.858	+0.583	<.001	.001	3	4
LSCC	ETV3 →	+0.566	+0.562	<.001	<.001	3	4
LUAD	BEX2 →	+1.834	+0.789	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,575 associations by consensus.

VANGL2 vs ARL8A — BRCA

Explore this scatter interactively →