VANGL2

Across TCGA patient cohorts, VANGL2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VANGL2-associated genes across cancer lineages are 14-3-3_beta, ERK2, and FOXO3a. Each is linked with VANGL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VANGL2-to-partner and partner-to-VANGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by VANGL2-low versus VANGL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VANGL2→partner) and Y-score (partner→VANGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.102	-3.973	<.001	<.001	3	2
UCEC	ERK2 →	+0.231	+1.807	<.001	<.001	3	2
UCEC	FOXO3a →	-0.079	-2.040	.008	.001	3	2
COAD	JNK2 →	+0.304	+2.815	.002	.036	3	2
UCEC	MEK1 →	+0.387	+2.321	<.001	<.001	3	2
UCEC	MSH2 →	-0.220	-2.295	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

14-3-3_beta by VANGL2 expression — UCEC

Explore this box plot interactively →