VANGL1

Across TCGA pan-cancer cohorts, VANGL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VANGL1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VANGL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VANGL1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where VANGL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	1.000	0.269	.005	25	view →
UCEC	OS	Median	All	0.863	0.980	.022	10	view →
LUAD	DFS	Quartile	All	0.825	0.945	.022	4	view →
GBM	DFS	Tertile	All	0.250	0.470	.047	4	view →
LSCC	OS	Tertile	All	0.916	0.753	.026	3	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.885	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VANGL1–CCRCC (DFS)

Open the CCRCC breakdown →