VANGL1

Across TCGA patient cohorts, VANGL1 mutation is significantly associated with the RNA expression of many other genes, with 3,025 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VANGL1-associated genes across cancer lineages are RNU6-728P, TMUB1, and PPP2R3B. Each is linked with VANGL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both VANGL1-to-partner and partner-to-VANGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-728P grouped by VANGL1-low versus VANGL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VANGL1→partner) and Y-score (partner→VANGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-728P →	+0.089	+2.381	.002	.007	3	3
UCEC	TMUB1 →	+0.295	+1.541	.006	.002	3	2
UCEC	PPP2R3B →	+0.364	+2.928	.002	<.001	3	2
UCEC	MAPK8IP2 →	+0.655	+2.180	<.001	.001	3	2
COAD	ASB15-AS1 →	+0.299	+5.516	<.001	.004	3	2
COAD	RN7SL687P →	+0.679	+5.516	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,025 associations by consensus.

RNU6-728P by VANGL1 expression — UCEC

Explore this box plot interactively →