VANGL1

Across TCGA patient cohorts, VANGL1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VANGL1-associated genes across cancer lineages are JNK2, Notch1, and PCNA. Each is linked with VANGL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VANGL1-to-partner and partner-to-VANGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by VANGL1-low versus VANGL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VANGL1→partner) and Y-score (partner→VANGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.211	+1.353	<.001	.015	3	2
UCEC	Notch1 →	+0.105	+1.713	.018	.024	3	2
UCEC	PCNA →	+0.152	+1.137	.025	.041	3	2
UCEC	ASNS →	+0.402	+1.662	<.001	.010	3	2
UCEC	Caspase-8 →	-0.207	-2.973	.008	<.001	3	2
UCEC	C-Raf →	+0.132	+1.502	.003	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

JNK2 by VANGL1 expression — UCEC

Explore this box plot interactively →