VANGL1

Across TCGA cell cohorts, VANGL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,309 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VANGL1-associated GO terms across cancer lineages are Cellular response to environmental stimulus, Positive regulation of mitotic cytokinesis, and Cellular response to abiotic stimulus. Each is linked with VANGL1 in more than 13 cancer types. Because this analysis shows association rather than direction, both VANGL1-to-partner and partner-to-VANGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to environmental stimulus grouped by VANGL1-low versus VANGL1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VANGL1→partner) and Y-score (partner→VANGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cellular response to environmental stimulus →	+0.048	+1.388	<.001	<.001	3	14
BREAST	Positive regulation of mitotic cytokinesis →	+0.179	+1.315	.001	<.001	3	14
BONE	Cellular response to abiotic stimulus →	+0.048	+1.388	<.001	<.001	3	14
BREAST	Cell division →	+0.087	+1.051	.001	.001	3	14
BREAST	Regulation of mitotic cytokinesis →	+0.167	+1.410	<.001	<.001	3	13
BREAST	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.179	+1.156	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,309 associations by consensus.

Cellular response to environmental stimulus by VANGL1 expression — BONE

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