VANGL1

Across TCGA cell cohorts, VANGL1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible VANGL1-associated genes across cancer lineages are C6orf118, PPDPFL, and C20orf85. Each is linked with VANGL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VANGL1-to-partner and partner-to-VANGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by VANGL1-low versus VANGL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VANGL1→partner) and Y-score (partner→VANGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.130	+3.115	<.001	.004	3	2
KIDNEY	PPDPFL →	+0.165	+4.121	.003	.006	3	1
SOFT_TISSUE	C20orf85 →	+0.086	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR1L4 →	+0.053	+4.369	<.001	.008	3	1
SOFT_TISSUE	IL3 →	+0.051	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4D6 →	+0.035	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

C6orf118 by VANGL1 expression — LARGE_INTESTINE

Explore this box plot interactively →