VAMP4

Across TCGA pan-cancer cohorts, VAMP4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VAMP4 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VAMP4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VAMP4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where VAMP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.898	0.503	<.001	26	view →
LSCC	OS	Tertile	All	0.827	0.924	.014	8	view →
LUAD	DFS	Median	II,III,IV	0.212	0.657	.014	4	view →
GBM	OS	Tertile	All	0.696	0.870	.048	1	view →
PDAC	DFS	Quartile	All	0.608	0.919	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VAMP4–HNSC (OS)

Open the HNSC breakdown →