VAMP4

Across TCGA patient cohorts, VAMP4 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAMP4-associated genes across cancer lineages are MBD3L3, LINC02871, and GPR6. Each is linked with VAMP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAMP4-to-partner and partner-to-VAMP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by VAMP4-low versus VAMP4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAMP4→partner) and Y-score (partner→VAMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	1
CESC	LINC02871 →	+0.132	+4.539	<.001	.008	3	1
CESC	GPR6 →	+0.037	+4.601	<.001	.004	3	1
CESC	LYZL2 →	+0.496	+4.193	.002	.009	3	1
CESC	SPPL2C →	+0.023	+4.601	.002	.004	3	1
CESC	KRTAP4-5 →	+0.096	+4.539	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

MBD3L3 by VAMP4 expression — COAD

Explore this box plot interactively →