VAMP4

Across TCGA patient cohorts, VAMP4 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAMP4-associated genes across cancer lineages are naive B-cells, MEP, and Endothelial cells. Each is linked with VAMP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAMP4-to-partner and partner-to-VAMP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, naive B-cells grouped by VAMP4-low versus VAMP4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAMP4→partner) and Y-score (partner→VAMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	naive B-cells →	+0.012	+3.922	.003	.020	3	1
UCEC	MEP →	+0.036	+3.010	.024	.020	1	2
UCEC	Endothelial cells →	-0.045	-2.957	.040	.037	1	1
UCEC	lymphatic Endothelial cells →	-0.031	-2.946	.024	.037	1	1
UCEC	mv Endothelial cells →	-0.028	-2.989	.042	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

naive B-cells by VAMP4 expression — CESC

Explore this box plot interactively →