VAMP3

Across TCGA pan-cancer cohorts, VAMP3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VAMP3 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher VAMP3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VAMP3 expression acts as an unfavorable survival marker.

OV, LIHC, and PCPG are the cancer types where VAMP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.022	0.844	<.001	48	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	12	view →
PCPG	DFS	Median	All	0.088	0.768	.002	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VAMP3–OV (OS)

Open the OV breakdown →