VAMP3

Across TCGA pan-cancer cohorts, VAMP3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VAMP3 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher VAMP3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VAMP3 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where VAMP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.512	0.896	.002	38	view →
PDAC	DFS	Median	III,IV	0.343	0.970	.003	20	view →
LUAD	DFS	Quartile	All	0.434	0.801	.020	8	view →
COAD	DFS	Median	III,IV	1.000	0.835	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VAMP3–LSCC (DFS)

Open the LSCC breakdown →