VAMP1

Across TCGA patient cohorts, VAMP1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAMP1-associated genes across cancer lineages are p27_pT198, TIGAR, and Tuberin_pT1462. Each is linked with VAMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAMP1-to-partner and partner-to-VAMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by VAMP1-low versus VAMP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAMP1→partner) and Y-score (partner→VAMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.132	+3.000	.032	.037	3	1
UCEC	TIGAR →	+0.190	+3.026	.031	.019	3	1
UCEC	Tuberin_pT1462 →	+0.364	+2.817	.006	.036	2	1
UCEC	MEK1 →	+0.557	+3.000	.008	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

p27_pT198 by VAMP1 expression — UCEC

Explore this box plot interactively →