VAC14

Across TCGA pan-cancer cohorts, VAC14 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VAC14 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher VAC14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VAC14 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, PDAC, and UCEC are the cancer types where VAC14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.883	1.000	.020	24	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	23	view →
UCEC	DFS	Median	All	0.935	1.000	.020	12	view →
LUAD	DFS	Quartile	II,III,IV	0.197	0.681	.022	6	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VAC14–COAD (DFS)

Open the COAD breakdown →