VAC14

Across TCGA patient cohorts, VAC14 protein abundance is significantly associated with the RNA expression of many other genes, with 10,077 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible VAC14-associated genes across cancer lineages are PLA2G15, KMO, and SIGLEC9. Each is linked with VAC14 in more than 4 cancer types. Because this analysis shows association rather than direction, both VAC14-to-partner and partner-to-VAC14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VAC14 versus PLA2G15 in COAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAC14→partner) and Y-score (partner→VAC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G15 →	+0.457	+0.131	<.001	.002	3	5
CCRCC	KMO →	+0.894	+0.258	.004	.007	3	5
COAD	SIGLEC9 →	+0.703	+0.192	<.001	<.001	3	5
COAD	APOC1 →	+1.192	+0.170	<.001	<.001	3	5
COAD	IGSF6 →	+0.753	+0.174	.002	.001	3	5
OV	MAP1LC3B →	+0.580	+0.370	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,077 associations by consensus.

VAC14 vs PLA2G15 — COAD

Explore this scatter interactively →