VAC14

Across TCGA patient cohorts, VAC14 mutation is significantly associated with the RNA expression of many other genes, with 4,840 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAC14-associated genes across cancer lineages are ELOCP22, XPNPEP1, and ACYP1. Each is linked with VAC14 in more than 2 cancer types. Because this analysis shows association rather than direction, both VAC14-to-partner and partner-to-VAC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOCP22 grouped by VAC14-low versus VAC14-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAC14→partner) and Y-score (partner→VAC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ELOCP22 →	+0.216	+4.536	<.001	.005	3	3
UCEC	XPNPEP1 →	+0.432	+1.906	<.001	<.001	3	3
UCEC	ACYP1 →	+0.317	+2.151	.007	.002	3	3
UCEC	GOT2 →	+0.467	+1.928	<.001	<.001	3	3
UCEC	RAB2B →	+0.382	+1.939	<.001	<.001	3	3
UCEC	SRRM1 →	+0.456	+2.534	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,840 associations by consensus.

ELOCP22 by VAC14 expression — HNSC

Explore this box plot interactively →