VAC14

Across TCGA patient cohorts, VAC14 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAC14-associated genes across cancer lineages are AR, Caspase-7-cleavedD198, and PR. Each is linked with VAC14 in more than 2 cancer types. Because this analysis shows association rather than direction, both VAC14-to-partner and partner-to-VAC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AR grouped by VAC14-low versus VAC14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAC14→partner) and Y-score (partner→VAC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AR →	-0.231	-1.201	.046	.028	3	3
COAD	Caspase-7-cleavedD198 →	+1.661	+3.008	<.001	.019	3	3
UCEC	PR →	-0.163	-1.700	.037	.040	3	2
UCEC	Tuberin_pT1462 →	+0.199	+1.257	.005	.027	3	2
UCEC	C-Raf →	+0.143	+1.847	.001	.007	3	2
UCEC	EGFR_pY1068 →	-0.161	-1.201	.039	.028	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

AR by VAC14 expression — UCEC

Explore this box plot interactively →