VAC14

Across TCGA cell cohorts, VAC14 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VAC14-associated genes across cancer lineages are SSMEM1, DRD5, and LCE3E. Each is linked with VAC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAC14-to-partner and partner-to-VAC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by VAC14-low versus VAC14-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAC14→partner) and Y-score (partner→VAC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SSMEM1 →	+0.054	+3.906	<.001	.002	3	2
URINARY_TRACT	DRD5 →	+0.078	+3.807	<.001	.005	3	1
URINARY_TRACT	LCE3E →	+0.180	+4.050	<.001	.002	3	1
LUNG_NSCLC_LUAD	SEL1L2 →	+0.027	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.037	+3.215	.001	.007	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.023	+4.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

SSMEM1 by VAC14 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →